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A polyvalent live Escherochia coli oral vaccine were prepared by the use of 5 field isolates of enteropathogenic E. coli, serotypes 08 : K87, K88a, b, 0138 : K81, K88a, c ; 0141 : K85a, b, K88a, b ; 0149 K9l, K88a, c and 0157 : K‘Vl7’, K88a, c. Some field experiments were conducted to investigate the effectiveness of the polyvalent live E. coli oral vaccine in the prevention of neonatal colibacillosis in piglets suckling orally vaccinated sows. Seventy-nine pregnant sows in an intensive pig farm were vaccinated with oral vaccine 4 weeks prior to farrowing and 19 sows were chosen for control. The piglets suck1ing vaccinated sows showed a significant protection against neonatal enteric colibacillosis during the 2 weeks observation period from the farrowing but no significant differences in protection between vaccinated and control group were observed with piglets older than 15 days.
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